• Neuronal cells have highly developed ER which makes

  2019-10-02

  

  Neuronal CP 154526 have highly developed ER, which makes them susceptible to loss of ER function following exposure to various agents, which leads to apoptosis (Lindholm et al., 2006, Katayama et al., 2004). Multiple pathways may be involved in ER stress-initiated apoptosis. Among them, the PKR-lik

• Our studies approached this problem using integrative

  2019-10-02

  

  Our studies approached this problem using integrative -omics analysis of human NK-ieILC1s from distinct microenvironments and functional subsets, including helper and adaptive phenotypes. At both the transcriptional and epigenetic levels, we find that the adaptive subset, CD57+ cytotoxic NK cells, s

• While a number of studies have helped elucidate the principl

  2019-10-02

  

  While a number of studies have helped elucidate the principles of target amino group specificity, UBL selectivity, and Ub topoisomerase inhibitors specificity [3], [4], [9], [10], [14], [19], [20], [23], [24], [33], [34], [37], [38], [39], [40], [41], the role of the canonical E2-RING interface in

• We have compared the potency

  2019-10-02

  

  We have compared the potency of a series of DNA-directed alkylating agents, including N-mustard-acridine, N-mustard-quinoline, and N-mustard-quinazoline conjugates previously synthesized in our laboratory [7], [13], and currently used drugs (oxaliplatin, cisplatin, or 5-FU) for the treatment of CRC

• br Conflicts of interest br Introduction Diacylglycerols DAG

  2019-10-02

  

  Conflicts of interest Introduction Diacylglycerols (DAGs) and phosphatidic Aminoallyl-dUTP kinase (PA) play fundamental roles in biology as basic components of membranes, intermediates in lipid metabolism, and secondary messengers in cellular signaling (Carrasco and Merida, 2007, Fang et al.,

• In conclusion over expression of Stokesia epoxygenase SlEPX

  2019-10-02

  

  In conclusion, over-expression of Stokesia epoxygenase (SlEPX) in soybean seeds led to some unusual seed phenotypes. These effects can be overcome by coexpression of Vernonia DGATs (VgDGAT1 & 2). The DGATs can specifically transfer vernolic 3\'-O-(2-nitrobenzyl)-2\'-dATP mass into TAG, largely redu

• br Acknowledgements The study was supported by grant no

  2019-10-02

  

  Acknowledgements The study was supported by grant no. 501-003-11043 from the Institute of Psychiatry and Neurology in Warsaw. The authors thank Mrs. Ala Biegaj for the excellent technical assistance. Introduction In an effort to identify hIFN receptor molecules encoded by a gene(s) within hum

• Physiological changes induced by CRF are mediated

  2019-10-02

  

  Physiological changes induced by CRF are mediated through CRF1 and CRF2 receptors (Chang et al., 1993, Lovenberg et al., 1995). Previous findings with CRF1 receptor antagonists showed that activation of CRF1 receptor is involved in maternal separation-induced ultrasonic vocalizations (Kehne et al.,

• Another option is to use the thiol groups of cysteine

  2019-10-02

  

  Another option is to use the thiol groups of cysteine residues, which can be modified by use of PEG-maleimide and vinyl sulfone. However, changes in PEGylation interactions or reaction conditions can result in changes in the functional properties of the therapeutic proteins [[50], [51], [52]]. A st

• Materials and methods br Results br Discussion Microbial pro

  2019-10-02

  

  Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino monobenzone and for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the exi

• There is a considerable molecular genetic heterogeneity

  2019-10-02

  

  There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions. Furthermore, for either gene fusion, additional heterogeneity stems from the location of the genomic breakpoints of the translocation, resulting in diffe

• The indigenous populations living at high mountain regions o

  2019-10-02

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human (S)-Methylisothiourea sulfate to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopul

• br Methods br Results br Discussion

  2019-10-02

  

  Methods Results Discussion The findings of this study indicate that an ET system including ET-1 and ET-2 as well as ET receptors are present in the retina and RPE/choroid, and are up-regulated by both hypertension and diabetes. Specifically, individual antagonism of the ETRA or ETRB deliver

• In terms of its protease activity

  2019-10-02

  

  In terms of its protease activity, MME has a broad range of substrates being able to target glucagon, bradykinin, GLP1, and several other BHQ kinase of circulating small molecules [25]. MME has been shown to target free insulin B-chain [32], although whether MME could target and degrade the insulin

• Our approach including the characterization of histone

  2019-10-01

  

  Our approach, including the characterization of histone modifications in scarce NK subsets, allowed us to identify super-enhancers, which associate with genes endowing a given cell type with its unique identity (Hnisz et al., 2013). Especially intriguing were SEs with distinct activities in NK subse

16114 records 955/1075 page Previous Next First page 上5页 951952953954955 下5页 Last page